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Your Guide to Treating Diabetes

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This content is created or selected by the Healthgrades editorial team and is funded by an advertising sponsor. The content is subject to the Healthgrades medical review process for accuracy, balance and objectivity. The content is not edited or otherwise influenced by the advertisers appearing on this page except with the possible suggestion of the broad topic area. For more information, read the Healthgrades advertising policy.

8 Tips for Diabetes Medication Self-Injections

Doctor William C Lloyd Healthgrades Medical Reviewer
Medically Reviewed By William C. Lloyd III, MD, FACS
Written By Evelyn Creekmore on August 13, 2021
  • man sitting on couch giving self insulin shot
    Master your diabetes injections to get the most from medication.
    In the United States, many adults living with diabetes use insulin injections or newer non-insulin injections to help keep their blood glucose levels under control. About one third of them, however, don’t inject their medication correctly. That means they don’t get the right amount of medication, their blood sugar levels swing too high or too low, and their diabetes symptoms get worse. Here are some easy ways to improve your technique.
  • Botox Treatment
    1. Confront your needle phobia.
    Some people struggle with taking their diabetes medication injections as prescribed because they’re afraid of needles. Fortunately, there are several ways to calm your fears. Ask your doctor if “exposure-based therapy” would help. It involves getting more comfortable with needles progressively—from just looking at a syringe without a needle, to looking at one with a needle, to holding one with a needle, and so on. Counseling can help, too.
  • female-patient-injecting-insulin-into-her-arm
    2. Ask about shorter needles.
    If the size of the needle is causing concern, you do have options–shorter needles are available! Experts used to think shorter needles weren’t effective for people who were overweight, but recent research has busted that myth. And no matter your weight, many studies have shown shorter needles are just as effective in delivering diabetes medication as longer needles. If your current needles are five to eight millimeters long, ask your doctor if it would be appropriate for you to switch to a four-millimeter needle. This needle is about as thin as a couple strands of hair.
  • nurse-explaining-diabetes-injectable
    3. Consider switching from needles to pens.
    Many people find a pen easier to handle, less painful, and more convenient. Whether or not a pen option is better for you will depend on the type of medication you take and other personal factors. Pens are available for insulin and the two different types of non-insulin injectable medications: GLP-1 receptor agonists and amylin analogues. GLP-1 receptor agonists stimulate your body to produce insulin. Amylin analogues slow the movement of food through your stomach to balance after-meal blood glucose levels. A pen is easy and quick to use, so if your syringe is causing problems, ask your doctor if it’s possible to switch to a medication that comes in pen form.
  • Caucasian woman opening refrigerator at night
    4. Keep diabetes medication—and yourself—at the right temperature.
    The temperature of both your medication and your body affects how fast you absorb injected diabetes medication. You don’t want your body to absorb it faster than intended. Insulin and GLP-1 receptor agonists should be kept refrigerated until they’re opened, then kept at room temperature. Amylin analogues should be kept refrigerated until opened, and then it can be kept at either room temperature or refrigerated. Hold off on diabetes injections after exercise or a hot bath or shower.
  • overhead view of unidentified Caucasian male preparing injectino pen on table
    5. Prep your needle or pen every time.
    Different medications and devices come with specific pre-injection steps. These may involve turning a dial on a pen to prime it or releasing a little medication before you inject it. Insulin pens and vials need to be tipped or rolled about 10 to 20 times before you use them. When you’re finished, the insulin should look clear, not cloudy. Check for air bubbles before you inject diabetes medication, and don’t hesitate to ask your doctor to demonstrate the entire process.
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  • diabetic woman self administering insulin shot into abdomen
    6. Choose your diabetes injection site and method wisely.
    Where you inject diabetes medication on your body affects the absorption rate. Research points to the abdomen as the ideal site for insulin, but it’s not the only effective option. Ask your doctor about the best spot for you. Some people find it easier to inject through clothes; this method has been shown to be safe and effective, as long as the clothes are clean and not thicker than one layer. Before you try this, get your doctor’s opinion.
  • man-injecting-diabetes-medication-into-arm
    7. Rotate your diabetes injection site regularly.
    You doctor may recommend injecting your diabetes medication in the abdomen, buttocks, upper thigh, or upper arm. This is meant to be a general area. Avoid injecting yourself in the exact same place, because that can cause lipohypertrophy—lumpy or toughened skin that decreases medication absorption. Nearly half of those who inject themselves with insulin experience lipohypertrophy, but you can avoid it by changing up where you inject. Be sure to avoid injecting diabetes medication into moles or scars, too.
  • gettyimages 74957233
    8. Prepare for hypoglycemia.
    Some people living with diabetes are so worried about hypoglycemia (low blood sugar) that they don’t take their diabetes medication injections. Hypoglycemia isn’t a common side effect of biologic injectables, but it is for insulin therapy. About 30% of people using insulin therapy experience it. While the hypoglycemia is not usually severe, you may want to keep a snack with at least 15 grams of carbohydrates on hand, or your doctor may prescribe glucagon injections in case of emergency.
How to Give Yourself Diabetes Injections Correctly: 8 Tips

About The Author

Evelyn Creekmore has more than 15 years of experience writing online educational health content, including nearly 10 years full-time at WebMD, where she was the director of brand content. She holds an MPH in Applied Public Health Informatics from Emory University Rollins School of Public Health and an MA from the University of North Carolina at Charlotte.
  1. Strategies for Insulin Injection Therapy in Diabetes Self-Management. American Association of Diabetes Educators. https://www.diabeteseducator.org/docs/default-source/legacy-docs/_resources/pdf/research/aade_meded.pdf?sfvrsn=2
  2. Insulin & Other Injectables. American Diabetes Association. http://diabetes.org/living-with-diabetes/treatment-and-care/medication/insulin/
  3. Other Injectable Medications. American Diabetes Association. http://diabetes.org/living-with-diabetes/treatment-and-care/medication/insulin/other-injectable-medications.html
  4. Interventions for Individuals With High Levels of Needle Fear. US National Library of Medicine National Institutes of Health. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900415/
    Nontraditional Considerations With Insulin Needle Length Selection. US National Library of Medicine National Institutes of Health. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647175/
  5. Am I Injecting Insulin Properly? Diabetes Forecast. http://www.diabetesforecast.org/2009/sep/am-i-injecting-insulin-properly.html
  6. The safety of injecting insulin through clothing. US National Library of Medicine National Institutes of Health. https://www.ncbi.nlm.nih.gov/pubmed/9051365
    Amylin Analog Treatment. University of California, San Francisco. https://dtc.ucsf.edu/types-of-diabetes/type2/treatment-of-type-2-diabetes/medications-and-therapies/type-2-non-insulin-therapies/amylin-analog-treatment/
  7. GLP-1 agonists: counselling points. The Pharmaceutical Journal. https://www.pharmaceutical-journal.com/news-and-analysis/glp-1-agonists-counselling-points/11127931.article
  8. Glucagon. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/glucagon-injection-route/description/drg-20064089
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Last Review Date: 2021 Aug 13
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.