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QUESTION & ANSWER
Q: Why do you take ranitidine at night?

By  Sarah Lewis, PharmD
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A:

Ranitidine decreases stomach acid production. Like other functions, stomach acid production has a circadian rhythm. It’s highest at night between 10:00 pm and 2:00 am. When ranitidine is used for ulcers, the dose is once a day at bedtime or twice daily. For heartburn, take it 30 minutes before eating problem foods.

More About Ranitidine

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Acid Reflux and GERD

About The Author

Sarah Lewis, PharmD Healthgrades Medical Writer
Sarah Lewis, PharmD
Sarah Lewis is a pharmacist and a medical writer with over 25 years of experience in various areas of pharmacy practice. Sarah holds a Bachelor of Science in Pharmacy degree from West Virginia University and a Doctor of Pharmacy degree from Massachusetts College of Pharmacy. She completed Pharmacy Practice Residency training at the University of Pittsburgh/VA Pittsburgh Healthcare System. 
Last Updated: April 27, 2020
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THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.
  1. H2 Blockers. U.S. National Library of Medicine. https://medlineplus.gov/ency/patientinstructions/000382.htm 
  2. Histamine H2 Antagonist (Oral Route, Injection Route, Intravenous Route). Mayo Foundation for Medical Education and Research. https://www.mayoclinic.org/drugs-supplements/histamine-h2-antagonist-oral-route-injection-route-intravenous-route/description/drg-20068584