Jardiance

Medically Reviewed By Alexandra Perez, PharmD, MBA, BCGP

Jardiance at a glance

Key highlights to know about Jardiance include:

  • Jardiance (empagliflozin) is used to improve blood sugar (glucose) in people with type 2 diabetes, along with diet and exercise. In people with type 2 diabetes and heart disease, Jardiance can reduce the risk of heart attack, stroke, and death. Jardiance is also used in people with heart failure (a condition where the heart is weak and cannot pump enough blood to the rest of the body) to lower the risk of heart attack, stroke, and death and to decrease hospitalization.
  • Jardiance is a tablet administered by mouth once each day in the morning, either with or without food.
  • Alcohol may cause a change in blood sugar. If you are concerned about taking Jardiance while drinking alcohol, talk with your doctor.
  • Jardiance is typically a high cost drug, which is defined in this article as costing more than $100 per month.
  • Jardiance is available as a brand-name drug only.

Important safety warnings for Jardiance

People who use Jardiance should be aware of these safety warnings:

  • Ketoacidosis warning: Jardiance can increase the risk of ketoacidosis (increased ketones in your blood or urine), which is a life threatening condition that requires urgent hospitalization. Signs and symptoms of ketoacidosis can include a loss of fluids (dehydration), nausea, vomiting, stomach pain, generalized fatigue (malaise), and difficulty breathing. Contact your healthcare professional or go to the emergency room right away if you experience these symptoms.
  • Dehydration (loss of fluids) warning: Jardiance can cause you to lose body water and salt. Dehydration may cause dizziness, lightheadedness, or weakness, especially when you stand up (orthostatic hypotension).
  • Serious urinary tract infection warning: Jardiance can increase the risk of serious urinary tract (bladder) infections, which may require hospitalization.
  • Low blood sugar (glucose) warning: If you take Jardiance with other diabetes medications that can cause low blood sugar, such as insulin or sulfonylureas, you may have a higher risk of experiencing episodes of low blood sugar (hypoglycemia).
  • Perineal infection warning: Jardiance can increase the risk of a rare but serious bacterial infection called necrotizing fasciitis in the area between and around the anus and genitals (perineum). Symptoms of necrotizing fasciitis of the perineum include pain or tenderness, redness (erythema), and swelling in the genital or perineal area, along with fever or fatigue (malaise). Seek medical attention immediately if you start to experience these symptoms.
  • Genital yeast infection warning: Jardiance can increase the risk of genital yeast (fungal) infections. Symptoms of a yeast infection include a foul odor coming from the area, discharge, pain, and itching of the genitals. Talk with your healthcare professional if you experience these symptoms. They may prescribe a medication to treat the infection.
  • Serious allergic reaction warning: Jardiance can cause serious allergic reactions. If you experience swelling of the face, lips, tongue, or throat or problems with swallowing or breathing, seek emergency care (call 911) right away.

Talk with your doctor about these warnings in the context of your individual treatment plan and medical history.

What Jardiance treats

This medication is used to:

  • lower blood sugar (glucose) in people with type 2 diabetes, along with diet and exercise
  • reduce the risk of heart attack, stroke, and death in adults with type 2 diabetes and heart disease
  • reduce the risk of heart attack, stroke, and death and decrease hospitalization in people with heart failure

Doctors sometimes prescribe medications for different uses. Ask your doctor or pharmacist for information about other uses for this medication.

How it works

Jardiance is an oral tablet that belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by blocking sugar (glucose) that has been filtered out of the body by the kidney from reentering the bloodstream. This extra glucose is then removed from the body when you urinate.

Jardiance is available as a tablet that is administered by mouth. It is available as a brand-name drug only.

Side effects of Jardiance

Jardiance side effects are possible and may go away with continued use. Serious side effects are rare.

Common side effects

The more common side effects that occur with Jardiance include:

  • urinary tract infections
  • vaginal yeast infections

Serious side effects

Call your doctor right away if you have serious side effects. Seek emergency care (call 911) if you experience life threatening symptoms, such as:

  • difficulty breathing
  • chest pain
  • a loss of consciousness
  • sudden vision changes
  • swelling of the face, mouth, tongue, or throat

Serious side effects and their symptoms can include the following:

  • Serious urinary tract (bladder) infections. Symptoms can include:
    • a need to urinate often
    • back pain
    • blood in your urine
    • a burning feeling when passing urine
    • fever
    • nausea or vomiting
    • pain in the lower part of your stomach (pelvis)
  • Low blood sugar (hypoglycemia). Symptoms can include:
    • confusion or drowsiness
    • dizziness or lightheadedness
    • a fast heartbeat
    • feeling jittery or shaky
    • headaches
    • hunger
    • irritability
    • sweating
    • weakness
  • Necrotizing fasciitis (bacterial infection) of the perineum (the area between and around the anus and genitals). Symptoms can include:
    • fever
    • fatigue (malaise)
    • pain or tenderness in the perineum
    • redness of the skin (erythema) in the perineum
    • swelling in the perineum
  • Vaginal yeast infection. Symptoms can include:
    • vaginal itching
    • vaginal odor
    • white or yellowish vaginal discharge, which may be lumpy or look like cottage cheese
  • Yeast infection of the penis (balanitis). Symptoms can include:
    • foul smelling discharge from the penis
    • painful skin around the penis
    • redness, itching, rash, or swelling of the penis
  • Serious allergic reaction. Symptoms can include:
    • difficulty swallowing or breathing
    • raised, red areas on the skin (hives)
    • swelling of the face, lips, throat, and other areas of the skin

Other side effects are possible. Talk with your doctor or pharmacist if you have any side effects that bother you or that do not go away.

Costs of Jardiance

Without insurance, Jardiance is typically a high cost drug, which is defined in this article as costing more than $100 per month. You can check the out-of-pocket cash pay price for Jardiance on prescription drug discount websites.

With insurance, prices can vary considerably. Individual health plans may have preferred drugs with better pricing. If the price of Jardiance on your health plan is too expensive, ask your doctor or pharmacist if there is an equivalent drug you can substitute.

How Jardiance may interact with other medications

Jardiance may interact with other prescription and over-the-counter medications, vitamins, or herbal supplements you may be taking. To help avoid harmful interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbal supplements you are taking. To find out how this drug might interact with something else you are taking, talk with your doctor or pharmacist.

This is not a complete list of drugs that may interact with Jardiance. However, examples of drugs that may interact with Jardiance include the following.

Diabetes medications that cause low blood sugar

If you take Jardiance with other diabetes medications that can cause low blood sugar, such as insulin or sulfonylureas, you may have a higher risk of having episodes of low blood sugar (hypoglycemia). Drugs include:

  • insulin (Lantus, Levemir, Novolog, Humalog)
  • sulfonylureas, such as:
    • glipizide (Glucotrol)
    • glimepiride (Amaryl)
    • glyburide (Glynase)

Blood pressure medications that cause fluid loss

If you take Jardiance with certain blood pressure medications that can cause fluid loss, such as loop diuretics (“water pills”), you may have a higher risk of having low blood pressure (hypotension) and increased fluid loss (dehydration). Drugs include:

  • bumetanide (Bumex)
  • furosemide (Lasix)
  • torsemide (Demadex)

Disclaimer: Since drugs interact differently in each person, this information is not guaranteed to include all possible interactions. This information is not a substitute for medical advice. Always talk with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbal supplements, and over-the-counter drugs you are taking.

Other Jardiance alerts

This drug comes with several alerts, including the following.

Type 1 diabetes

Jardiance is not for use in people with type 1 diabetes.

Dosage changes

Your doctor may need to adjust your prescribed dosage of Jardiance if you experience any of the following changes:

  • a change in your diet
  • a change in your alcohol consumption habits (drinking alcohol very often)
  • illness or fever
  • infection
  • surgery

Severe kidney problems

In people with severe kidney problems, Jardiance may not work as well as it should, and it may be more likely to cause side effects.

Do not use Jardiance if you are on dialysis. People with impaired kidney function, older adults, and individuals taking loop diuretics (“water pills”) may be at increased risk of fluid loss or low blood pressure (hypotension).

Your doctor may test how well your kidneys are working before beginning treatment and while you are taking Jardiance.

Warnings for other groups

Jardiance has not been studied in children or adolescents younger than 18 years of age.

While taking Jardiance, call your doctor right away if you have serious side effects. Seek emergency care (call 911) if you experience life threatening symptoms, such as:

  • difficulty breathing
  • chest pain
  • a loss of consciousness
  • sudden vision changes
  • swelling of the face, mouth, tongue, or throat

Your healthcare professional will give you instructions on how to monitor your blood sugar. Your doctor or pharmacist can also teach you how to prevent, recognize, and manage low blood sugar (hypoglycemia), high blood sugar (hyperglycemia), and problems you have because of your diabetes.

For pregnant and breastfeeding people

The following sections contain information that may be useful if you are pregnant or breastfeeding.

Can I take Jardiance when pregnant?

Jardiance may harm the fetus. Jardiance is not recommended during the second and third trimesters of pregnancy. If you plan on becoming pregnant or become pregnant while taking Jardiance, talk with your doctor as soon as possible. They will help determine the best way to manage your blood sugar levels while pregnant.

Can I take Jardiance when breastfeeding?

Jardiance may pass into your breast milk and harm your baby. Do not breastfeed while taking Jardiance. Talk with your doctor about the best way to feed your baby if you are taking Jardiance.

How and when to take Jardiance

This drug is administered by mouth once in the morning each day, either with or without food. You may take this medication with or without other diabetes medications.

All possible dosages and forms may not be included here. Your dosage, your form, and how often you take Jardiance will depend on:

  • other prescribed diabetes medications
  • other medical conditions you have
  • how you tolerate the medication

Drug forms and strengths

Jardiance comes in the form of a tablet. It is available in the following strengths:

  • 10 milligrams (mg)
  • 25 mg

Dosage for type 2 diabetes

  • Initial: You will take 10 mg by mouth one time each morning.
  • Maximum: You can take 25 mg by mouth one time each morning. Your doctor may prescribe the 25-mg dose if your blood sugar (glucose) is not adequately controlled on the 10-mg dose.

Dosage for reducing the risk of heart attack, stroke, and death in people with diabetes and heart disease:

  • Initial: You will take 10 mg by mouth one time each morning.
  • Maximum: You can take 25 mg by mouth one time each morning. Your doctor may prescribe the 25-mg dose if your blood sugar (glucose) is not adequately controlled on the 10-mg dose.

Dosage for reducing the risk of heart attack, stroke, hospitalization, and death in people with heart failure:

  • Initial: You will take 10 mg by mouth one time each morning.
  • Maximum: You can take 25 mg by mouth one time each morning. Your doctor may prescribe the 25-mg dose if your blood sugar (glucose) is not adequately controlled on the 10-mg dose.

If you miss a dose of Jardiance

If you miss a dose of Jardiance, take the missed dose as soon as you remember it. If you do not remember the same day and it is close to the time of your next dose, take your regular dose at your next usual time and skip the missed dose. Do not take more than your prescribed dose. Do not double the dose (take two doses at one time) the next day.

If you take too much Jardiance

If you take too much Jardiance, you have a higher risk of experiencing side effects from this drug. If you think you have taken too much Jardiance, call your doctor, seek emergency care, or call the local poison control center at 800-222-1222.

Seek emergency care (call 911) if you experience life threatening symptoms, such as:

  • difficulty breathing
  • chest pain
  • a loss of consciousness
  • sudden vision changes
  • swelling of the face, mouth, tongue, or throat

Helpful tips when taking Jardiance

Keep these considerations in mind if your doctor prescribes Jardiance for you.

General

  • Administer Jardiance by mouth once each day in the morning.
  • Jardiance can be taken with or without food.
  • Follow all exercise and dietary recommendations your doctor makes. Also, follow their instructions about drinking enough fluids throughout the day while you are taking this medication.

Storage

  • Jardiance should be kept at room temperature between 68°F and 77°F (20°C and 25°C).
  • Jardiance can still be used if it is temporarily exposed to temperatures between 59°F and 86°F (15°C and 30°C).
  • Store Jardiance securely with the lid on tightly, protect it from moisture and humidity, and keep it out of reach of children.
  • Do not leave Jardiance in a car or another place where it could get too hot or too cold.

Alcohol

Alcohol may cause a change in blood sugar. If you are concerned about taking Jardiance while drinking alcohol, talk with your doctor.

Refills

Your doctor will write the number of authorized refills on your prescription. Talk with your pharmacist if you have questions about refills.

Travel

When planning to travel, keep these tips in mind for packing your medication:

  • Bring enough medication for the full number of days of your trip, plus at least 2 days to be safe.
  • When flying, keep your medication with you in a purse or a carry-on bag. Do not put it into a checked bag in case you are separated from your luggage.
  • Keep your medications in their original containers, if possible, to reduce delays during airport or security screening. Keep all your medications together to quicken the process.
  • Avoid leaving your medication in a parked car for extended periods to protect it from extreme temperatures.

Clinical monitoring

  • Your doctor will monitor how well Jardiance is working using regular blood tests for your blood sugar (glucose) and hemoglobin A1C levels.
  • Before having any laboratory test, tell your doctor that you are taking Jardiance. Your urine may test positive for glucose (because of the way the medication works).

Availability

Many pharmacies stock this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it and has it in stock.

Prior authorization

Many insurance companies require a prior authorization for this drug. This means that your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Medications similar to Jardiance

Jardiance belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors, which are used for type 2 diabetes.

Other SGLT2 inhibitors prescribed for diabetes include:

  • canagliflozin (Invokana)
  • dapagliflozin (Farxiga)
  • ertuglifozin (S

    teglatro)

Each medication has its own benefits and side effects. Your doctor will help determine the best option for you.
There are also some medications that are combination drugs that include the active ingredient in Jardiance (empagliflozin) combined with other diabetes medications. These include:

  • empagliflozin/linagliptin (Glyxambi)
  • empagliflozin/metformin (Synjardy)
  • empagliflozin/linagliptin/metformin (Trijardy XR)

Discontinuing use of Jardiance

Do not stop taking this drug unless instructed by your doctor.

Healthgrades disclaimer

This information is for educational purposes only. It should not be interpreted as medical advice, diagnosis, or treatment. Healthgrades takes every effort to ensure this information is accurate and up to date. This content is not intended to cover all possible uses, side effects, warnings, precautions, allergic reactions, or drug interactions. Do not assume that the absence of such information means the medication is safe for your personal use. Always consult your doctor, pharmacist, or healthcare professional before taking or discontinuing any medication.

Medical Reviewer: Alexandra Perez, PharmD, MBA, BCGP
Last Review Date: 2022 Feb 11
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.