Ingrezza's Side Effects: What to Know

Medically Reviewed By Elizabeth Scheffel, PharmD

Ingrezza: Introduction

Ingrezza is a brand-name prescription drug. It’s a type of medication called a vesicular monoamine transporter 2 inhibitor.

Ingrezza contains the active drug valbenazine, and it comes as an oral capsule that you swallow.

Ingrezza is approved by the Food and Drug Administration (FDA) to treat tardive dyskinesia in adults.

Doctors can prescribe Ingrezza for long-term use. Similar to other drugs, Ingrezza may cause side effects. Read below for information about possible side effects, including common, mild, and serious ones.

For a general overview of Ingrezza, see this article.

If you’d like to take Ingrezza, search here to find a healthcare professional who might prescribe it.

Ingrezza: More common side effects

Some of Ingrezza’s side effects may be more common than others. These side effects may last only a few days to weeks. However, some side effects may last longer or become severe or bothersome. Tell your doctor or pharmacist if you have concerns about any side effects of Ingrezza.

In Ingrezza’s clinical studies, these were some side effects that occurred more often:

* For more information about this side effect, see “Ingrezza: Side effects explained” below.

Ingrezza: Mild side effects

Ingrezza can cause mild side effects, which are listed below. However, this list doesn’t include all possible mild side effects. To learn more about Ingrezza’s side effects, view the drug’s prescribing information.

Ingrezza’s mild side effects include:

The side effects listed above may last only a few days to weeks. However, some side effects may last longer or become severe or bothersome. Tell your doctor or pharmacist if you have concerns about side effects of Ingrezza.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking Ingrezza and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see “Ingrezza: Side effects explained” below.

Ingrezza: Serious side effects

It’s possible to have serious side effects with Ingrezza. Serious side effects are listed below, but this list may not include all possibilities. To learn more about Ingrezza’s side effects, view the drug’s prescribing information.

Call your doctor right away if you have serious side effects with Ingrezza. However, if you think you’re having a medical emergency or have life threatening side effects, call 911 or your local emergency number.

Serious side effects of Ingrezza and their possible symptoms include:

* An allergic reaction is possible after taking Ingrezza. However, this side effect was not reported in clinical studies. For more information about this side effect, see “Ingrezza: Side effects explained” below.

Ingrezza: Common questions about side effects

Here are some common questions about the drug’s side effects and answers to them. Talk with your doctor if you have other questions about this drug.

Will I have side effects if I stop taking Ingrezza?

It’s not likely. Withdrawal symptoms weren’t reported in clinical studies of Ingrezza. (Withdrawal symptoms are side effects that can happen when you stop taking a drug your body is dependent on.)

However, the symptoms of tardive dyskinesia (TD) may return after stopping the drug. (Ingrezza is used to treat TD.) If your doctor tells you it’s safe to stop taking Ingrezza, watch for symptoms such as involuntarily smacking your lips, sticking out your tongue, or blinking. These could be signs that your TD symptoms are returning.

If you’d like to stop taking Ingrezza, talk with your doctor first. They may want to switch you to a different treatment option for your condition.

Do side effects of Ingrezza vary with its dosage?

It’s possible for higher doses of Ingrezza to increase your risk of certain side effects. However, the side effects themselves don’t vary.

For example, in clinical studies, the risk of Parkinsonism increased at higher doses of Ingrezza. (Parkinsonism is a condition that causes unusual body movements, such as tremors or trouble walking.)

Talk with your doctor about your risk of side effects with Ingrezza based on the dosage you’re prescribed.

Is rash a side effect of Ingrezza?

Maybe. Rash wasn’t reported as a side effect in clinical studies of Ingrezza. However, rash has been reported since the drug became available to the public.

Keep in mind that a rash is a possible symptom of an allergic reaction. For more information about this side effect, see “Ingrezza: Side effects explained” below.

If you have a rash while taking Ingrezza, talk with your doctor. They can advise whether this may be a side effect of Ingrezza. However, if your symptoms seem severe or life threatening, this could be a sign of a serious allergic reaction. In this case, call 911 or your local emergency number right away.

Ingrezza: Side effects explained

Here’s detailed information about some of Ingrezza’s side effects.

Weight gain

Weight gain may occur with Ingrezza. However, this was a rare side effect in clinical studies of the drug.

What to do

If you have bothersome or unplanned weight gain while taking Ingrezza, talk with your doctor. They can suggest exercise routines or diet plans to help you manage a body weight that is healthy for you.

Problems with digestion

Ingrezza may cause certain problems with digestion. Constipation was a more common side effect in clinical studies of the drug, while nausea and vomiting were less common.

What to do

If you find that Ingrezza causes nausea or vomiting, try taking your dose with food. (Ingrezza may be taken with food or without it.) Doing so may help ease your symptoms.

If you have bothersome constipation, nausea, or vomiting while taking Ingrezza, talk with your doctor. They can suggest ways to ease your symptoms. Below are a few treatments they may recommend:

  • for constipation, over-the-counter (OTC) laxatives such as senna (Senokot) or bisacodyl (Dulcolax)
  • for nausea, OTC drugs such as bismuth subsalicylate (Pepto-Bismol) or meclizine (Dramamine, Bonine, others)
  • for vomiting, OTC drugs such as meclizine (Dramamine, Bonine, others)

Urinary retention

Urinary retention may occur with Ingrezza. This was one of the more common side effects in clinical studies of the drug.

Urinary retention is not being able to fully empty your bladder. Symptoms can include:

What to do

If you have urinary retention while taking Ingrezza, talk with your doctor. They may switch you to a different treatment that doesn’t cause this side effect.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Ingrezza. A more severe allergic reaction is rare but possible.

Possible symptoms of mild and serious allergic reactions are listed in the table below.

Mild allergic reaction symptoms Serious allergic reaction symptoms
• itching trouble breathing
rash • swelling in your throat or mouth
flushing • swelling under your skin, possibly in your hands, feet, lips, or eyelids

If you have an allergic reaction to Ingrezza, call your doctor right away. This is important to do because the reaction could become severe.

However, if you’re having a medical emergency or your symptoms feel life threatening, call 911 or your local emergency number.

Ingrezza: Precautions

Be sure to talk with your doctor about your health history before you take Ingrezza. This drug may not be the right treatment option for you if you have certain medical conditions or other factors that affect your health.

The conditions and factors to consider include those described below.

Abnormal heart rhythm. If you have an abnormal heart rhythm, talk with your doctor before taking Ingrezza. The drug may cause long QT syndrome (a type of abnormal heart rhythm). This side effect could worsen an abnormal heart rhythm in people who already have this condition. Your doctor can advise whether Ingrezza is a safe treatment option for you.

Liver problems. Be sure to tell your doctor if you have liver problems, such as liver failure. If you have liver problems, you may have an increased risk of side effects with Ingrezza. For this reason, your doctor may prescribe a lower dosage of Ingrezza than is typical.

Allergic reaction. If you’ve had an allergic reaction to Ingrezza or any of its ingredients, your doctor will likely not prescribe Ingrezza. Ask your doctor what other medications may be better options for you.

Consuming alcohol during Ingrezza treatment

There is no known interaction between Ingrezza and alcohol.

However, your doctor may recommend that you avoid drinking alcohol while taking Ingrezza. Drinking alcohol could worsen sleepiness, which is a possible side effect of Ingrezza.

Talk with your doctor or pharmacist before consuming alcohol while taking Ingrezza.

Pregnancy and breastfeeding during Ingrezza treatment

It isn’t known whether Ingrezza is safe to take while pregnant or breastfeeding.

Animal studies have shown harm to offspring of pregnant animals who received the drug. In addition, Ingrezza has been found in the milk of lactating animals who received the drug. Keep in mind that what happens in animals doesn’t always happen in humans.

To be safe, doctors may advise that you do not take Ingrezza while pregnant or breastfeeding. They may also recommend that you avoid breastfeeding for at least 5 days after your last dose of Ingrezza.

If you’re pregnant, breastfeeding, or planning either, talk with your doctor. They can explain the risks and benefits of taking Ingrezza during these times.

Ingrezza: What to discuss with your doctor

Talk with your doctor or pharmacist to find out more information about Ingrezza. If you have questions about the drug’s side effects, your pharmacist or healthcare professional can help answer them for you.

In addition to discussing Ingrezza with your doctor, you may find the following articles helpful in learning more.

  • Overview of Ingrezza. To read an overview of Ingrezza, see this article.
  • Drug comparison. To learn how Ingrezza compares with Austedo, read this article. And for a comparison with Klonopin, see this article.
  • Details about tardive dyskinesia. To learn more about tardive dyskinesia, which Ingrezza is used to treat, see this tardive dyskinesia article.

Disclaimer: Healthgrades has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Medical Reviewer: Elizabeth Scheffel, PharmD
Last Review Date: 2022 May 30
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.